Label-free single-molecule detection of DNA-hybridization kinetics with a carbon nanotube field-effect transistor
نویسندگان
چکیده
منابع مشابه
Label-free single-molecule detection of DNA-hybridization kinetics with a carbon nanotube field-effect transistor.
Single-molecule measurements of biomolecules can provide information about the molecular interactions and kinetics that are hidden in ensemble measurements. However, there is a requirement for techniques with improved sensitivity and time resolution for use in exploring biomolecular systems with fast dynamics. Here, we report the detection of DNA hybridization at the single-molecule level using...
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1. Fabrication of devices 2. Lifetime histograms with probe DNA NH2-5’-GGAAAAAAGG-3’ (Device 1) 3. Measurements with probe DNA NH2-5’-GTGAGTTGTT-3’ (Device 2) 4. Lifetime histograms with probe DNA NH2-5’-GTGAGTTGTT-3’ (Device 2) 5. Control experiment with a non-functionalized device 6. Scanning gate microscopy (IV) 7. Control experiments with probe DNA NH2-5’-GGAAAAAAGG-3’ with complementary an...
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ژورنال
عنوان ژورنال: Nature Nanotechnology
سال: 2011
ISSN: 1748-3387,1748-3395
DOI: 10.1038/nnano.2010.275